Neutrophils are the most abundant immune cells in the human body. However, our knowledge about their role in cancer progression and therapy-resistance is limited.

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We have recently shown, that upon treatment with T cell-based immunotherapies neutrophils are recruited into the TME and tumor-draining lymph nodes. Here, they acquire an immune-suppressive phenotype, impairing T cell function and limiting the efficacy of immunotherapies (Glodde et al., 2017).

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In this project, we aim to understand the molecular mechanisms leading to the recruitment of neutrophils, driving their phenotypic plasticity and are involved in regulating T cell function, in order to develop novel neutrophil-targeting cancer immunotherapies.