Neutrophils: Friend or Foe? //
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Neutrophils are the most abundant immune cells in the human body. However, our knowledge about their role in cancer progression and therapy-resistance is limited.
We have recently shown, that upon treatment with T cell-based immunotherapies neutrophils are recruited into the TME and tumor-draining lymph nodes. Here, they acquire an immune-suppressive phenotype, impairing T cell function and limiting the efficacy of immunotherapies (Glodde et al., 2017).
In this project, we aim to understand the molecular mechanisms leading to the recruitment of neutrophils, driving their phenotypic plasticity and are involved in regulating T cell function, in order to develop novel neutrophil-targeting cancer immunotherapies.